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Supporting your MPS II journey

HOW IS ELAPRASE DOSED?

ELAPRASE dosing and infusion set up

Nurse preparing an ELAPRASE infusion

The dose of ELAPRASE given depends on the patient's weight, so you or your child should be regularly weighed to allow the optimal dose to be calculated. ELAPRASE is a weekly infusion therapy, which means it’s given intravenously (by IV).

To receive ELAPRASE therapy, you will have to go to a treatment center every week. At the treatment center, a healthcare professional will administer the therapy and can answer any questions you may have.

Typically, the infusion can take up to 3 hours, but patients may require longer infusion times if hypersensitivity reactions occur. There also may be additional time for preparation and observation. Your healthcare provider can give you more details about what to expect and can help you plan ahead.

Each infusion center has its own guidelines about what patients are permitted to do while undergoing therapy, and it may be OK to engage in a quiet activity, such as reading a book, watching TV on a personal device, or doing homework. Check with your treatment center before you arrive to find out what activities are permitted.

Patients who tolerate the infusions well may be able to gradually shorten their infusion time to 1 hour.

Where permitted by local healthcare and reimbursement policy, patients who tolerate ELAPRASE infusions well over several months may be able to receive infusions at home under the supervision of a healthcare professional. Speak to your doctor for more information about home infusions.

As with any new experience, receiving ELAPRASE infusions might feel daunting at first, or the process might even make you or your child nervous. Talk to your doctor about any concerns you have.

ELAPRASE patient during an infusion
Important Safety Information
Important Safety Information

RISK OF SERIOUS ALLERGIC REACTIONS

Some patients have experienced serious allergic reactions (including life-threatening anaphylactic reactions) during and up to 24 hours after treatment, regardless of how long they were taking ELAPRASE. Anaphylactic reactions are immediate and include breathing problems, low oxygen levels, low blood pressure, hives and/or swelling of the throat or tongue. If a patient (you or your child) has experienced an anaphylactic reaction, the patient may require an extended period of observation by the patient’s healthcare team. If you or your child has breathing problems, a fever, or a respiratory illness, you or your child may be at risk of life-threatening worsening of those conditions due to allergic reactions from ELAPRASE. Your healthcare team should be advised of those conditions before treatment with ELAPRASE because the information may affect the timing of ELAPRASE treatment.